Rootine BioKnow™ Test

DNA Test  Blood Test Urine Test

Analyze 50+ genetic variants and 80+ blood and urine metabolites that determine exactly how your body absorbs, distributes, metabolizes, and excretes 19 vital nutrients.

This test reveals the key factors that determine the exact dose and form of each nutrient that you need daily to best support your unique body.

DNA, Blood & Urine Analysis

Detailed, Actionable Insights

Easy To Understand

Nutrigenetics + Metabolomics

Rootine BioKnow™ Test

DNA Test  Blood & Urine Test

Analyze 50+ genetic variants and 80+ blood and urine metabolites to determine how your body absorbs, distributes, metabolizes, and excretes 19 vital nutrients.

This test reveals key factors that determine the exact dose and form of each nutrient to best support your unique body.

125+ Markers

Test 125+ Markers

Reveal Sources Of















Vitamin E


Vitamin B1

Vitamin B12




Vitamin B5

Vitamin B6


Vitamin K


HFE (3)









Mitochondrial Function




Protein Intake

Protein Breakdown

Carb Metabolism

Kidney Stone Risk


Ammonia Detoxification


Heavy Metal Detox


Liver Function

Free Radicals


And much more...

  • 1- Methyl-histidine
  • 2Hhippurate
  • 2HIC
  • 2HPA
  • 2KG
  • 3HB
  • 3HIV
  • 3HP3HP
  • 4AB
  • 4HBA
  • 4Hhippurate
  • 4HPA
  • 4HPL
  • 5HindoleAA
  • 5HM2F
  • Adipate
  • Analog Cit
  • b-Ala
  • Benzonate
  • Beta-AminoIsoButyric Acid
  • C0
  • Carnosine
  • Cisaconate
  • Citrate
  • Cysteine
  • EMA
  • Formiminoglutamate
  • Fumarate
  • Gln
  • Glutamine
  • Glutarate
  • Gly1
  • Glycerate
  • Glycine
  • Glycolate
  • Hippurate1
  • His
  • Histidine
  • HMG2
  • HVA
  • Indole3AA
  • isoLeu
  • Kynurate
  • Lactate
  • Leu
  • Lys1
  • Malate
  • Mandelate
  • Me-succinate
  • Methionine
  • MMA
  • Orotate
  • Oxalate
  • Phe1
  • Phenylalanine
  • Proline
  • PyroGlu
  • Pyruvate
  • Sarcosine
  • Sebacate
  • Ser1
  • Serine
  • Suberate
  • Succinate
  • Tartarate
  • Thr
  • VMA
  • Xanthurenic acid
  • Biotin (B7)
  • Valine
  • Vitamin B3
  • ADRB1
  • AGT
  • APOA1
  • APOA5
  • APOB
  • APOE (2)
  • CETP
  • CFH
  • CHD13
  • CHDS8
  • Col1A1
  • ESR1
  • FTO
  • GJA4
  • GNB3
  • GPX1
  • GSTM1
  • GSTP1
  • GSTT 1
  • HFE (3)
  • HHEX
  • HIGD1C
  • HTRA1
  • IL10
  • IL1A
  • IL6
  • ITGB3
  • KCNJ11
  • LCT
  • LOC387715
  • MMP3
  • MTRR
  • NOS1AP (3)
  • NOS3 (3)
  • NQO1
  • PON1 (2)
  • SOD2
  • SREBF2
  • TCF7L2
  • TNFa
  • VDR

Meet Your Metabolism

  • Does CoQ10 work in my body?
  • Do I need the active form of folate (B9)?
  • Is iron slowly poisoning me?
  • Do I need 2x the vitamin D?
  • Am I eating enough protein?
  • Am I efficiently detoxifying heavy metals?
  • How healthy are my mitochondria?
  • Do I process carbohydrates well?
  • And much more...

Personalized & Easy Next Steps

Results come with a research-backed and AI generated nutrient recommendation based on your DNA, Blood, and Urine results. You can order this exact personalized formula of 19 key nutrients, dose accurately to the milligram, at any time.

  • Vitamin E, C, B2, B6, B9 (folate), B12, D3
  • Magnesium, Manganese, Zinc, Selenium, Calcium, Copper, Iron
  • Alpha Lipoic Acid, phytosterols, MSM, Omega-3s, CoQ10

How It Works

Completed the test in your home in about 5 minutes. A cheek swab (obtains DNA), a finger-prick, and a urine sample is required. The samples are returned to the envelope and shipped to our medical-grade laboratory (postage included).

We perform analysis and generate easy-to-understand recommendations for each nutrient.

Superior Testing

DNA analysis reveals how your body absorbs, distributes, metabolizes, and excretes nutrients due to common slight variations in your genetic code. This is the science of nutrigenetics.

The blood and urine metabolite analysis details how well nutrients are performing their functions and how efficiently key metabolic processes are occurring (like the detoxification of heavy metals and neutralization of free radicals). This is the science of metabolomics.

BioKnow™ Test FAQs

What will the blood test tell me?

Blood data is great for determining initial nutrient dosing and also for tracking how nutrient levels change over time, which is valuable information used to adjust doses and learn how nutrition therapies or lifestyle changes impact your health. Our metabolite test does the same thing, but we track nutrient function instead of nutrient level.

Already have blood nutrient test results from another source, like a physician? Easily upload the data into your Rootine dashboard.

Why have I never heard of metabolite testing?

Metabolite analysis has been used by the medical community for some time; however, it was too expensive in the past to be offered as a consumer product. It's an extremely complex test that analyzes 80+ metabolites via mass spectroscopy and there are only a few labs in the world that have this capability. Thankfully, our lab is one of them and we're able to bring this exciting technology to you.

I already have blood data, can I upload?

Yes, as long as the blood data corresponds to nutrient levels (we cannot process other markers, like cholesterol or hsCRP) you can manually upload these values in your dashboard and they will be used to guide nutrient dosing. Simply complete the free lifestyle quiz, enter your dashboard, and enter the values that you have (if you don't have all of values that is not an issue). More info can be found in our complete FAQ.

How long does it take?

From the time our lab receives your test kit, analysis can take anywhere from 3-5 weeks based on the quality of your samples. You'll receive an email when analysis is complete and your Rootine dashboard will include your results and recommendations.

Is my data private?

Your data is 100% private - plain and simple. Rootine is not in the business of selling personal data or using it for any purpose other than making sure that your body gets the precision nutrition it deserves. Our industry-leading genetics laboratory is governed by some of the strictest data and medical privacy laws in the world.

Metabolite blood test vs. traditional blood test

Traditional blood testing shows how much of a nutrient is in the blood, referred to as the "blood level" of said nutrient. However, many factors influence how a nutrient actually functions in a body and the level only reveals how you compare to the population standards. Your optimal range for each nutrient could be considerably higher or lower than the norm. Metabolite testing shows you the dose required based on what is going on within your body.

Your Experts

Dr. Wallerstorfer, PhD
Co-Founder & CTO
Dr. Diaz, PharmD
Clinical Advisor
Rachel Sanders
Co-Founder & CEO
Dr. Harris MD
Clinical Advisor
Jordan Mazur RD
Clinical Advisor / NFL
Tye Jensen BS
Founding Team