The GPX-1 Gene and Your Selenium Needs

The GPX-1 Gene and Your Selenium Needs

There are 52 genes that are currently known to impact nutrient needs.  The GPX-1 gene is one of them. Here is what you need to know:

What is the GPX-1 Gene

The GPX-1 gene produces a protein that protects us from the damaging effects of free radicals (which can damage tissue and speed up the aging process).

How Does the GPX-1 Gene Work?

To function properly, the GPX-1 gene requires selenium, which means it is important to make sure that you are getting the right amount of selenium given your genetic blueprint. 

What Does the GPX-1 Gene Tell Us About Selenium?

A simple at home DNA test enables you to find out if you are part of the one third of the population that has a genetic variation which reduces the effectiveness of the GPX-1 gene.

If so, your body is likely not as good at protecting itself from the damaging effects of free radicals.  This means you may benefit from taking additional selenium to counteract the effect of your genetics. 

The Science Behind GPX-1’s Interaction with Selenium

There are three genotypes for the GPX1 gene: C/C, C/T, and T/T. The C/C genetic type is the normal, protected type. Two thirds of the population has this genetic result.  Approximately one third of the population has genotypes C/T and T/T, which are considered genetic variations that cause GPX-1 gene activity to be significantly reduced.  

The table below outlines nine independent peer reviewed studies that each confirm that a genetic variation in the GPX1 gene limits protection against oxidative stress and free radicals.

GPX-1 Gene Variation Science

(Note: in medical genetics, three quality studies are seen as sufficient scientific backing, and in this case we have 3x that amount)

Ways to Counteract the Effect of Your GPX-1 Gene Variation

Studies have shown that carriers of the genotypes C/T and T/T can boost their GPX-1 activity by supplementing with higher doses of selenium. It is thought that with extra selenium, more of the less-effective enzyme is being produced, making up for this genetic handicap.

Have additional questions about how your GPX-1 gene affects your selenium needs? Email our Chief Scientist and co-founder, Daniel Wallerstorfer, PhD at



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